Acute phosphate nephropathy after bowel cleansing: still a menace.
نویسندگان
چکیده
Dear editor: Colonoscopy is critically dependent on adequate pre-procedural bowel cleansing and oral sodium phosphate bowel purgatives (OSP) have been used with good acceptance and efficacy for this purpose. Among others metabolic and clinical disturbances described after the procedure, acute kidney injury may be a serious complication. We present two cases of sodium phosphate induced acute renal failure.
منابع مشابه
Kidney biopsies taken before and after oral sodium phosphate bowel cleansing.
Acute renal failure due to phosphate nephropathy following bowel cleansing with an oral sodium phosphate solution is a rare, but well-known, complication [1]. Several authors have reported diffuse tubular injury and tubular deposition of calcium phosphate in biopsies taken from such patients [1–4]. In these patients, the term acute phosphate nephropathy more aptly describes this entity than the...
متن کاملAcute phosphate nephropathy.
PURPOSE OF REVIEW Acute phosphate nephropathy (APN) has been identified in renal biopsy specimens of patients exposed to oral sodium phosphate (OSP) bowel purgatives. Biopsy confirmed cases presented with bland urinary sediment, low-grade proteinuria, and varying degrees of creatinine elevation. Prospective identification of APN is difficult in that definitive diagnosis requires renal biopsy, a...
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Prior to colonoscopy, bowel cleansing is performed for which frequently oral sodium phosphate (OSP) is used. OSP results in significant hyperphosphatemia and cases of acute kidney injury (AKI) referred to as acute phosphate nephropathy (APN; characterized by nephrocalcinosis) are reported after OSP use, which led to a US-FDA warning. To improve the safety profile of OSP, it was evaluated whethe...
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BACKGROUND Oral sodium phosphate solutions (OSPS) are widely used for bowel cleansing prior to colonoscopy and other procedures. Cases of renal failure due to acute phosphate nephropathy following OSPS ingestion have been documented in recent years, questioning the safety of OSPS. However, the magnitude of the problem remains unknown. METHODOLOGY/PRINCIPAL FINDINGS We conducted a population b...
متن کاملAcute phosphate nephropathy due to use of phosphorous enema: Case report
Acute phosphate nephropathy is a rare but serious type of kidney injury that commonly occurs after the use of bowel purgatives that contain oral sodium phosphate. Bowel purgatives are widely used to prepare patients for colonoscopy, but their use can cause acute or chronic kidney disease. Acute phosphate nephropathy is a type of crystal nephropathy characterized by tubular and interstitial depo...
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عنوان ژورنال:
- Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia
دوره 30 6 شماره
صفحات -
تاریخ انتشار 2010